Faculty ProfilesJohn Newman, MD, PhD
4150 Clement St
San Francisco, CA 94121
Dr. Newman is a geriatrician, basic science researcher, and educator in the Division of Geriatrics at UCSF. As a physician-scientist, Dr. Newman hopes to translate what we are learning of the pathways that control fundamental mechanisms of aging into therapies that will improve the health and preserve the independence of older adults.
His research work is in the laboratory of Eric Verdin at the Buck Institute for Research on Aging, and focuses on how ketone bodies, small molecules that our bodies make for energy when we fast or exercise, also act as molecular signals to control inflammation and gene expression. The signaling functions of ketone bodies may be translational targets for protecting cognition and improving resilience in older adults. This is one example how environmental cues like diet and fasting signal through small metabolites in our cells to regulate the genes and pathways that in turn control aging. Dr. Newman is particularly interested in testing if harnessing these signals can protect older adults from the risks of hospitalization like delirium and functional decline.
Dr. Newman attends on the inpatient medicine service and the acute care of elders unit at the San Francisco VA Medical Center, with a clinical focus on delirium and functional decline. He teaches students, residents, and fellows about geriatric clinical problems, as well as about the biology of aging and emerging translational science in geriatrics. He works as a part of the national Geroscience Network to develop frameworks and resources for testing interventions that target fundamental mechanisms of aging in clinical trials. He seeks to bridge the community of basic scientists that study aging to geriatricians and other clinicians who study the clinical problems of aging in order to develop innovative translational therapies.
Dr. Newman completed an MD/PhD at the University of Washington in Seattle, then residency training in Internal Medicine and a fellowship in Geriatrics at UCSF before joining the faculty in 2014. Dr. Newman is a 2014 Beeson Scholar from the National Institute on Aging and the American Federation of Aging Research. His work has also been supported by generous funding from the Larry L. Hillblom Foundation and the Glenn Foundation for Medical Research.
Assistant Professor, Division of Geriatrics at UCSF
Visiting Scientist, Gladstone Institutes
Geriatrician, San Francisco VA Medical Center
Education and Training
|Location||Degree or Training||Specialty||Date|
|University of Washington||MD/PhD||Biochemistry||2008|
|Yale University||BS/MS||Molecular Biophysics and Biochemistry||2000|
Geriatrics, acute care of elders, aging, dietary restriction, epigenetics, frailty, gene expression, ketone bodies, longevity, metabolismAwards and Honors
John S. Spice Award in Aging, Larry L. Hillblom Foundation, 2014
Beeson Scholar, National Institute on Aging and American Federation for Aging Research, 2014-2019
Award of Excellence in Scientific Leadership, Gladstone Institute of Virology and Immunology, 2013
Glenn Award for Research in Biological Mechanisms of Aging, Paul F. Glenn Foundation, 2013
Postdoctoral Fellowship, Larry L. Hillblom Foundation, 2012-2015
Hartford Scholar, John A. Hartford Foundation, 2011-2013
Related Web Sites
Recent Articles (27)
Tognini P, Murakami M, Liu Y, Eckel-Mahan KL, Newman JC, Verdin E, Baldi P, Sassone-Corsi P. Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet. Cell Metab. 2017 Sep 05; 26(3):523-538.e5.
Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell Metab. 2017 Sep 05; 26(3):547-557.e8.
Newman JC, Milman S, Hashmi SK, Austad SN, Kirkland JL, Halter JB, Barzilai N. Strategies and Challenges in Clinical Trials Targeting Human Aging. J Gerontol A Biol Sci Med Sci. 2016 Nov; 71(11):1424-1434.
Justice J, Miller JD, Newman JC, Hashmi SK, Halter J, Austad SN, Barzilai N, Kirkland JL. Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes. J Gerontol A Biol Sci Med Sci. 2016 Nov; 71(11):1415-1423.
Shirakawa K, Wang L, Man N, Maksimoska J, Sorum AW, Lim HW, Lee IS, Shimazu T, Newman JC, Schröder S, Ott M, Marmorstein R, Meier J, Nimer S, Verdin E. Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife. 2016 May 31; 5.
Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, Guo A, Gut P, Sahu AK, Li B, Uppala R, Fitch M, Riiff T, Zhu L, Zhou J, Mulhern D, Stevens RD, Ilkayeva OR, Newgard CB, Jacobson MP, Hellerstein M, Goetzman ES, Gibson BW, Verdin E. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab. 2013 Dec 03; 18(6):920-33.
Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6601-6.
Feldman R, Newman J. Copyright at the Bedside: Should We Stop the Spread?. Stanford Technology Law Review. 2013; 16(3):623.
Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, Grueter CA, Lim H, Saunders LR, Stevens RD, Newgard CB, Farese RV, de Cabo R, Ulrich S, Akassoglou K, Verdin E. Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 2013 Jan 11; 339(6116):211-4.
Bailey AD, Gray LT, Pavelitz T, Newman JC, Horibata K, Tanaka K, Weiner AM. The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells. DNA Repair (Amst). 2012 May 01; 11(5):488-501.
Cahan P, Rovegno F, Mooney D, Newman JC, St Laurent G, McCaffrey TA. Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization. Gene. 2007 Oct 15; 401(1-2):12-8.
Schutzman JL, Borland CZ, Newman JC, Robinson MK, Kokel M, Stern MJ. The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction. Mol Cell Biol. 2001 Dec; 21(23):8104-16.