Faculty ProfilesW. John Boscardin
4150 Clement Street
W. John Boscardin, Ph.D. is a biostatistician with a joint appointment as Professor of Medicine and Epidemiology & Biostatistics. His primary role with the Department of Medicine is as Director of the Statistical Laboratory for the Division of Geriatrics and for SFVAMC Health Services Research. The laboratory is comprised of six Master's and Ph.D. level statisticians and provides data management, analytic support, and methodological input to more than a dozen principal investigators in geriatrics and health services. He is also one of the biostatistics faculty members for the CTSI K-Scholars Program based out of the Department of Epidemiology & Biostatistics, serving as statistical mentor to numerous junior investigators over the past several years. Dr. Boscardin received his Ph.D. in Statistics in 1996 from the University of California, Berkeley. He was a faculty member at UCLA in the Departments of Biostatistics and Medicine before moving to UCSF in 2008. His areas of methodological expertise include analysis of longitudinal and repeated measures data, treatment of missing data, Bayesian statistical modeling, and computational statistics. He has worked in a wide range of substantive areas including HIV/AIDS, brain injury, health disparities, diabetes, stroke, ageing and frailty, and scleroderma, with colleagues in a wide variety of disciplines, including geriatrics, psychology, psychiatry, pediatrics, ophthalmology, immunology, virology, gastroenterology, epidemiology, neuroimaging, neurosurgery, neuroscience, cardiology, health services, and rheumatism.
Recent Articles (95)
Meyer AC, Boscardin WJ, Kwasa JK, Price RW. Is It Time to Rethink How Neuropsychological Tests Are Used to Diagnose Mild Forms of HIV-Associated Neurocognitive Disorders? Impact of False-Positive Rates on Prevalence and Power. Neuroepidemiology. 2013; 41(3-4):208-16.
Bardach NS, Wang JJ, De Leon SF, Shih SC, Boscardin WJ, Goldman LE, Dudley RA. Effect of pay-for-performance incentives on quality of care in small practices with electronic health records: a randomized trial. JAMA. 2013 Sep 11; 310(10):1051-9.
Bardach NS, Vittinghoff E, Asteria-Peñaloza R, Edwards JD, Yazdany J, Lee HC, Boscardin WJ, Cabana MD, Dudley RA. Measuring hospital quality using pediatric readmission and revisit rates. Pediatrics. 2013 Sep; 132(3):429-36.
Mihalis EL, Wysong A, Boscardin WJ, Tang JY, Chren MM, Arron ST. Factors affecting sunscreen use and sun avoidance in a U.S. national sample of organ transplant recipients. Br J Dermatol. 2013 Feb; 168(2):346-53.
Chren MM, Linos E, Torres JS, Stuart SE, Parvataneni R, Boscardin WJ. Tumor recurrence 5 years after treatment of cutaneous Basal cell carcinoma and squamous cell carcinoma. J Invest Dermatol. 2013 May; 133(5):1188-96.
Pierluissi E, Mehta KM, Kirby KA, Boscardin WJ, Fortinsky RH, Palmer RM, Landefeld CS. Depressive symptoms after hospitalization in older adults: function and mortality outcomes. J Am Geriatr Soc. 2012 Dec; 60(12):2254-62.
Bardach NS, Asteria-Peñaloza R, Boscardin WJ, Dudley RA. The relationship between commercial website ratings and traditional hospital performance measures in the USA. BMJ Qual Saf. 2013 Mar; 22(3):194-202.
Aragon K, Covinsky K, Miao Y, Boscardin WJ, Flint L, Smith AK. Use of the Medicare posthospitalization skilled nursing benefit in the last 6 months of life. Arch Intern Med. 2012 Nov 12; 172(20):1573-9.
Gogia R, Binstock M, Hirose R, Boscardin WJ, Chren MM, Arron ST. Fitzpatrick skin phototype is an independent predictor of squamous cell carcinoma risk after solid organ transplantation. J Am Acad Dermatol. 2013 Apr; 68(4):585-91.
Meyer AC, Dua T, Boscardin WJ, Escarce JJ, Saxena S, Birbeck GL. Critical determinants of the epilepsy treatment gap: A cross-national analysis in resource-limited settings. Epilepsia. 2012 Dec; 53(12):2178-85.
Barnes DE, Mehta KM, Boscardin WJ, Fortinsky RH, Palmer RM, Kirby KA, Landefeld CS. Prediction of recovery, dependence or death in elders who become disabled during hospitalization. J Gen Intern Med. 2013 Feb; 28(2):261-8.
Yau CK, Eng C, Cenzer IS, Boscardin WJ, Rice-Trumble K, Lee SJ. Glycosylated hemoglobin and functional decline in community-dwelling nursing home-eligible elderly adults with diabetes mellitus. J Am Geriatr Soc. 2012 Jul; 60(7):1215-21.
Smith AK, McCarthy E, Weber E, Cenzer IS, Boscardin J, Fisher J, Covinsky K. Half of older Americans seen in emergency department in last month of life; most admitted to hospital, and many die there. Health Aff (Millwood). 2012 Jun; 31(6):1277-85.
Hiramoto JS, Owens CD, Kim JM, Boscardin J, Belkin M, Creager MA, Conte MS. Sex-based differences in the inflammatory profile of peripheral artery disease and the association with primary patency of lower extremity vein bypass grafts. J Vasc Surg. 2012 Aug; 56(2):387-95; discussion 395.
Gelfand JM, Goodin DS, Boscardin WJ, Nolan R, Cuneo A, Green AJ. Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progressive phenotypes. PLoS One. 2012; 7(5):e36847.
Yu KC, Nettar KD, Bapna S, Boscardin WJ, Maas CS. Split-face double-blind study comparing the onset of action of onabotulinumtoxinA and abobotulinumtoxinA. Arch Facial Plast Surg. 2012 May-Jun; 14(3):198-204.
Lee SJ, Boscardin WJ, Stijacic-Cenzer I, Conell-Price J, O'Brien S, Walter LC. Time lag to benefit after screening for breast and colorectal cancer: meta-analysis of survival data from the United States, Sweden, United Kingdom, and Denmark. BMJ. 2012; 346:e8441.
O'Hare AM, Choi AI, Boscardin WJ, Clinton WL, Zawadzki I, Hebert PL, Kurella Tamura M, Taylor L, Larson EB. Trends in timing of initiation of chronic dialysis in the United States. Arch Intern Med. 2011 Oct 10; 171(18):1663-9.
Anton PA, Saunders T, Elliott J, Khanukhova E, Dennis R, Adler A, Cortina G, Tanner K, Boscardin J, Cumberland WG, Zhou Y, Ventuneac A, Carballo-Diéguez A, Rabe L, McCormick T, Gabelnick H, Mauck C, McGowan I. First phase 1 double-blind, placebo-controlled, randomized rectal microbicide trial using UC781 gel with a novel index of ex vivo efficacy. PLoS One. 2011; 6(9):e23243.
Nettar KD, Yu KC, Bapna S, Boscardin J, Maas CS. An internally controlled, double-blind comparison of the efficacy of onabotulinumtoxinA and abobotulinumtoxinA. Arch Facial Plast Surg. 2011 Nov-Dec; 13(6):380-6.
Mehta KM, Pierluissi E, Boscardin WJ, Kirby KA, Walter LC, Chren MM, Palmer RM, Counsell SR, Landefeld CS. A clinical index to stratify hospitalized older adults according to risk for new-onset disability. J Am Geriatr Soc. 2011 Jul; 59(7):1206-16.
Chung JH, Phibbs CS, Boscardin WJ, Kominski GF, Ortega AN, Gregory KD, Needleman J. Examining the effect of hospital-level factors on mortality of very low birth weight infants using multilevel modeling. J Perinatol. 2011 Dec; 31(12):770-5.
Lee SJ, Boscardin WJ, Stijacic Cenzer I, Huang ES, Rice-Trumble K, Eng C. The risks and benefits of implementing glycemic control guidelines in frail older adults with diabetes mellitus. J Am Geriatr Soc. 2011 Apr; 59(4):666-72.
Steinman MA, Lund BC, Miao Y, Boscardin WJ, Kaboli PJ. Geriatric conditions, medication use, and risk of adverse drug events in a predominantly male, older veteran population. J Am Geriatr Soc. 2011 Apr; 59(4):615-21.
Wirtschafter DD, Powers RJ, Pettit JS, Lee HC, Boscardin WJ, Ahmad Subeh M, Gould JB. Nosocomial infection reduction in VLBW infants with a statewide quality-improvement model. Pediatrics. 2011 Mar; 127(3):419-26.
Steinman MA, Hanlon JT, Sloane RJ, Boscardin WJ, Schmader KE. Do geriatric conditions increase risk of adverse drug reactions in ambulatory elders? Results from the VA GEM Drug Study. J Gerontol A Biol Sci Med Sci. 2011 Apr; 66(4):444-51.
Stein JC, Wang R, Adler N, Boscardin J, Jacoby VL, Won G, Goldstein R, Kohn MA. Emergency physician ultrasonography for evaluating patients at risk for ectopic pregnancy: a meta-analysis. Ann Emerg Med. 2010 Dec; 56(6):674-83.
Gordon WJ, Polansky JM, Boscardin WJ, Fung KZ, Steinman MA. Coronary risk assessment by point-based vs. equation-based Framingham models: significant implications for clinical care. J Gen Intern Med. 2010 Nov; 25(11):1145-51.
Kelly A, Conell-Price J, Covinsky K, Cenzer IS, Chang A, Boscardin WJ, Smith AK. Length of stay for older adults residing in nursing homes at the end of life. J Am Geriatr Soc. 2010 Sep; 58(9):1701-6.
Chung JH, Phibbs CS, Boscardin WJ, Kominski GF, Ortega AN, Needleman J. The effect of neonatal intensive care level and hospital volume on mortality of very low birth weight infants. Med Care. 2010 Jul; 48(7):635-44.
Wagner J, Dusick JR, McArthur DL, Cohan P, Wang C, Swerdloff R, Boscardin WJ, Kelly DF. Acute gonadotroph and somatotroph hormonal suppression after traumatic brain injury. J Neurotrauma. 2010 Jun; 27(6):1007-19.
Grudzen CR, Hoffman JR, Koenig WJ, Boscardin J, Lorenz KA, Asch SM. The LA story: what happened after a new policy allowing paramedics to forgo resuscitation attempts in prehospital cardiac arrest. Resuscitation. 2010 Jun; 81(6):685-90.
Tang JY, Parimi N, Wu A, Boscardin WJ, Shikany JM, Chren MM, Cummings SR, Epstein EH, Bauer DC. Inverse association between serum 25(OH) vitamin D levels and non-melanoma skin cancer in elderly men. Cancer Causes Control. 2010 Mar; 21(3):387-91.
Newman PA, Lee SJ, Duan N, Rudy E, Nakazono TK, Boscardin J, Kakinami L, Shoptaw S, Diamant A, Cunningham WE. Preventive HIV vaccine acceptability and behavioral risk compensation among a random sample of high-risk adults in Los Angeles (LA VOICES). Health Serv Res. 2009 Dec; 44(6):2167-79.
Stone GW, Martin JL, de Boer MJ, Margheri M, Bramucci E, Blankenship JC, Metzger DC, Gibbons RJ, Lindsay BS, Weiner BH, Lansky AJ, Krucoff MW, Fahy M, Boscardin WJ. Effect of supersaturated oxygen delivery on infarct size after percutaneous coronary intervention in acute myocardial infarction. Circ Cardiovasc Interv. 2009 Oct; 2(5):366-75.
FitzGerald JD, Boscardin WJ, Ettner SL. Changes in regional variation of Medicare home health care utilization and service mix for patients undergoing major orthopedic procedures in response to changes in reimbursement policy. Health Serv Res. 2009 Aug; 44(4):1232-52.
Robinson PL, Boscardin WJ, George SM, Teklehaimanot S, Heslin KC, Bluthenthal RN. The effect of urban street gang densities on small area homicide incidence in a large metropolitan county, 1994-2002. J Urban Health. 2009 Jul; 86(4):511-23.
Wong MD, Ettner SL, Boscardin WJ, Shapiro MF. The contribution of cancer incidence, stage at diagnosis and survival to racial differences in years of life expectancy. J Gen Intern Med. 2009 Apr; 24(4):475-81.
Fatemi N, Dusick JR, Mattozo C, McArthur DL, Cohan P, Boscardin J, Wang C, Swerdloff RS, Kelly DF. Pituitary hormonal loss and recovery after transsphenoidal adenoma removal. Neurosurgery. 2008 Oct; 63(4):709-18; discussion 718-9.
Anton PA, Ibarrondo FJ, Boscardin WJ, Zhou Y, Schwartz EJ, Ng HL, Hausner MA, Shih R, Elliott J, Hultin PM, Hultin LE, Price C, Fuerst M, Adler A, Wong JT, Yang OO, Jamieson BD. Differential immunogenicity of vaccinia and HIV-1 components of a human recombinant vaccine in mucosal and blood compartments. Vaccine. 2008 Aug 18; 26(35):4617-23.
Bavisetty S, Bavisetty S, McArthur DL, Dusick JR, Wang C, Cohan P, Boscardin WJ, Swerdloff R, Levin H, Chang DJ, Muizelaar JP, Kelly DF. Chronic hypopituitarism after traumatic brain injury: risk assessment and relationship to outcome. Neurosurgery. 2008 May; 62(5):1080-93; discussion 1093-4.
McGowan I, Elliott J, Cortina G, Tanner K, Siboliban C, Adler A, Cho D, Boscardin WJ, Soto-Torres L, Anton PA. Characterization of baseline intestinal mucosal indices of injury and inflammation in men for use in rectal microbicide trials (HIV Prevention Trials Network-056). J Acquir Immune Defic Syndr. 2007 Dec 1; 46(4):417-25.
Gonzalez NR, Boscardin WJ, Glenn T, Vinuela F, Martin NA. Vasospasm probability index: a combination of transcranial doppler velocities, cerebral blood flow, and clinical risk factors to predict cerebral vasospasm after aneurysmal subarachnoid hemorrhage. J Neurosurg. 2007 Dec; 107(6):1101-12.
Epeldegui M, Breen EC, Hung YP, Boscardin WJ, Detels R, Martínez-Maza O. Elevated expression of activation induced cytidine deaminase in peripheral blood mononuclear cells precedes AIDS-NHL diagnosis. AIDS. 2007 Nov 12; 21(17):2265-70.
Weng HH, Kaplan RM, Boscardin WJ, Maclean CH, Lee IY, Chen W, Fitzgerald JD. Development of a decision aid to address racial disparities in utilization of knee replacement surgery. Arthritis Rheum. 2007 May 15; 57(4):568-75.
FitzGerald JD, Mangione CM, Boscardin J, Kominski G, Hahn B, Ettner SL. Impact of changes in Medicare Home Health care reimbursement on month-to-month Home Health utilization between 1996 and 2001 for a national sample of patients undergoing orthopedic procedures. Med Care. 2006 Sep; 44(9):870-8.
Poles MA, Boscardin WJ, Elliott J, Taing P, Fuerst MM, McGowan I, Brown S, Anton PA. Lack of decay of HIV-1 in gut-associated lymphoid tissue reservoirs in maximally suppressed individuals. J Acquir Immune Defic Syndr. 2006 Sep; 43(1):65-8.
Breen EC, Fatahi S, Epeldegui M, Boscardin WJ, Detels R, Martínez-Maza O. Elevated serum soluble CD30 precedes the development of AIDS-associated non-Hodgkin's B cell lymphoma. Tumour Biol. 2006; 27(4):187-94.
Pedroza-Martins L, Boscardin WJ, Anisman-Posner DJ, Redsar BN, Bryson YJ, Yang OO, Uittenbogaart CH. Interferon-gamma decreases replication of primary R5 HIV-1 isolates in thymocytes. AIDS. 2006 Apr 4; 20(6):939-42.
Widney DP, Breen EC, Boscardin WJ, Kitchen SG, Alcantar JM, Smith JB, Zack JA, Detels R, Martínez-Maza O. Serum levels of the homeostatic B cell chemokine, CXCL13, are elevated during HIV infection. J Interferon Cytokine Res. 2005 Nov; 25(11):702-6.
Oertel M, Boscardin WJ, Obrist WD, Glenn TC, McArthur DL, Gravori T, Lee JH, Martin NA. Posttraumatic vasospasm: the epidemiology, severity, and time course of an underestimated phenomenon: a prospective study performed in 299 patients. J Neurosurg. 2005 Nov; 103(5):812-24.
Breen EC, Epeldegui M, Boscardin WJ, Widney DP, Detels R, Martínez-Maza O. Elevated levels of soluble CD44 precede the development of AIDS-associated non-Hodgkin's B-cell lymphoma. AIDS. 2005 Oct 14; 19(15):1711-2.
Fonarow GC, Adams KF, Abraham WT, Yancy CW, Boscardin WJ. Risk stratification for in-hospital mortality in acutely decompensated heart failure: classification and regression tree analysis. JAMA. 2005 Feb 2; 293(5):572-80.
Bergsneider M, Yang I, Hu X, McArthur DL, Cook SW, Boscardin WJ. Relationship between valve opening pressure, body position, and intracranial pressure in normal pressure hydrocephalus: paradigm for selection of programmable valve pressure setting. Neurosurgery. 2004 Oct; 55(4):851-8; discussion 858-9.
McGowan I, Elliott J, Fuerst M, Taing P, Boscardin J, Poles M, Anton P. Increased HIV-1 mucosal replication is associated with generalized mucosal cytokine activation. J Acquir Immune Defic Syndr. 2004 Oct 1; 37(2):1228-36.
Breen EC, Boscardin WJ, Detels R, Jacobson LP, Smith MW, O'Brien SJ, Chmiel JS, Rinaldo CR, Lai S, Martínez-Maza O. Non-Hodgkin's B cell lymphoma in persons with acquired immunodeficiency syndrome is associated with increased serum levels of IL10, or the IL10 promoter -592 C/C genotype. Clin Immunol. 2003 Nov; 109(2):119-29.
Chung JH, Boscardin WJ, Garite TJ, Lagrew DC, Porto M. Ethnic differences in birth weight by gestational age: at least a partial explanation for the Hispanic epidemiologic paradox? Am J Obstet Gynecol. 2003 Oct; 189(4):1058-62.
Glenn TC, Kelly DF, Boscardin WJ, McArthur DL, Vespa P, Oertel M, Hovda DA, Bergsneider M, Hillered L, Martin NA. Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism. J Cereb Blood Flow Metab. 2003 Oct; 23(10):1239-50.
Widney D, Boscardin WJ, Kasravi A, Martínez-Maza O. Expression and function of CD28 on Epstein-Barr virus-positive B cell lines and AIDS-associated non-Hodgkin's lymphoma cell lines. Tumour Biol. 2003 Mar-Apr; 24(2):82-93.
Oertel M, Kelly DF, Lee JH, McArthur DL, Glenn TC, Vespa P, Boscardin WJ, Hovda DA, Martin NA. Efficacy of hyperventilation, blood pressure elevation, and metabolic suppression therapy in controlling intracranial pressure after head injury. J Neurosurg. 2002 Nov; 97(5):1045-53.
Yang OO, Boscardin WJ, Matud J, Hausner MA, Hultin LE, Hultin PM, Shih R, Ferbas J, Siegal FP, Shodell M, Shearer GM, Grene E, Carrington M, O'Brien S, Price CB, Detels R, Jamieson BD, Giorgi JV. Immunologic profile of highly exposed yet HIV type 1-seronegative men. AIDS Res Hum Retroviruses. 2002 Sep 20; 18(14):1051-65.
Pedroza-Martins L, Boscardin WJ, Anisman-Posner DJ, Schols D, Bryson YJ, Uittenbogaart CH. Impact of cytokines on replication in the thymus of primary human immunodeficiency virus type 1 isolates from infants. J Virol. 2002 Jul; 76(14):6929-43.
Vespa PM, Boscardin WJ, Hovda DA, McArthur DL, Nuwer MR, Martin NA, Nenov V, Glenn TC, Bergsneider M, Kelly DF, Becker DP. Early and persistent impaired percent alpha variability on continuous electroencephalography monitoring as predictive of poor outcome after traumatic brain injury. J Neurosurg. 2002 Jul; 97(1):84-92.
Oertel M, Kelly DF, McArthur D, Boscardin WJ, Glenn TC, Lee JH, Gravori T, Obukhov D, McBride DQ, Martin NA. Progressive hemorrhage after head trauma: predictors and consequences of the evolving injury. J Neurosurg. 2002 Jan; 96(1):109-16.
Lee JH, Kelly DF, Oertel M, McArthur DL, Glenn TC, Vespa P, Boscardin WJ, Martin NA. Carbon dioxide reactivity, pressure autoregulation, and metabolic suppression reactivity after head injury: a transcranial Doppler study. J Neurosurg. 2001 Aug; 95(2):222-32.
Breen EC, McDonald M, Fan J, Boscardin J, Fahey JL. Cytokine gene expression occurs more rapidly in stimulated peripheral blood mononuclear cells from human immunodeficiency virus-infected persons. Clin Diagn Lab Immunol. 2000 Sep; 7(5):769-73.