Research Education Component
The Research Education Component identifies, supports, and nurtures talented junior investigators who will become national leaders in aging research.
The Core’s mentorship and curricular programs help junior investigators progress along the pathways that lead to high impact publications and grant funding that develops the scholar’s national reputation as a leader in their area. Mentoring services, seminar series, and resource core services are also available to investigators whose goals are to develop careers in aging research. A particular focus of the Associate Scholars Program is junior faculty who have trained outside of geriatric medicine, but seek to incorporate Geriatric principles into their developing research program.
The Research Education Component also sponsors a Diversity Supplement Program to increase the number of faculty members from underrepresented and diverse backgrounds conducting aging research at UCSF.
Louise Walter, MD
Professor of Medicine, Chief, Division of Geriatrics, Associate Director, UCSF Clinical and Translational Science Institute KL2 Program, Director, Health Services Research & Development Program (SFVAMC), Geriatrician, SFVAMC
Highlighted Research Education Component Scholars
Jennifer Lai, MD, MBA
Assistant Professor, Division of Hepatology
Project: A Pilot Randomized Trial for a Home-Based, Structured Exercise Program to Improve Physical Function in Older Liver Transplant Candidates
Dr. Lai conducted an observational study of functional status in liver transplant candidates. Support from the Pepper Center enabled her to engage in analyses evaluating the role of frailty in mortality prediction.
Since receiving funding from the Pepper Center, Dr. Lai subsequently was awarded the American Gastroenterological Association-Elsevier Pilot Award and a UCSF Department of Medicine Patient Cohort Expansion Award. She also received the American Society of Transplantation Clinical Science Career Development Award, a Poster of Distinction at the American Association for the Study of Liver Diseases Liver Meeting, and was selected to be an AFAR Dorothy Dillon Eweson Lecturer on the Advances in Aging Research.
Sei Lee, MD, MAS
Associate Professor, Division of Geriatrics
Project: Development and Validation of a Life Expectancy Calculator for Veterans
The inability to effectively incorporate life expectancy into clinical decision making leads to poor targeting of preventive interventions, resulting in net harm for younger patients with limited life expectancy and missed benefits for older patients with extended life expectancy. Dr. Lee will use national VA electronic data (demographics, disease diagnoses, laboratory results and pharmacy records) to develop a 10 year Life Expectancy Calculator that can be imbedded into the VA electronic health record, and he will internally and externally validate the Calculator. This study will provide a critical advance in the prediction of life expectancy that will improve the targeting of a wide range of prevention interventions in older Veterans. Colorectal cancer screening, prostate specific antigen testing, breast cancer screening, glycemic control and blood pressure control all are associated with immediate risks and delayed benefits. The electronic, data-driven life expectancy calculator will provide the information clinicians need at the point-of-care to individualize prevention decisions and improve the targeting of prevention, maximizing benefits and minimizing harms.
Dr. Lee provides an example of how the UCSF Pepper Center supports researchers across career stages. He was initially supported by the Resource Education Core, which provided career development support to accelerate the transition from K (Beeson) status to independent R01 status by supporting the preliminary work needed to develop the R01 application. Dr. Lee is currently joint-PI with Dr. Smith on a R01 project to develop and validate prognostic indices to predict mortality and functional decline in community-dwelling elders. The RDAC core provides statistical support and assists with state of the art approaches towards prognostic model validation. The DMAC core provides assistance with the use of functional measures in the HRS dataset. Dr. Lee and Smith are now using their R01 platform to provide mentorship and support to recently funded REC scholars.
In addition to his subsequent R01 funding, Dr. Lee was also awarded a VA HSR&D IIR entitled: Development and Validation of 10-Year Life Expectancy Calculators to Individualize Veterans’ Prevention Decisions.
Elena Portacolone, PhD, MBA, MPH
Assistant Professor, UCSF School of Nursing, Institute of Health Aging
Project: The Social Isolation of Older Americans Living in High-Crime Neighborhoods: Root Causes and Possible Solutions
Very little is known about the experience of older residents of high-crime neighborhoods. It is important to expand our knowledge on this population because older residents of high-crime neighborhoods are likely to be socially isolated and at risk for poor health outcomes. This study aimed to build knowledge of culturally-sensitive clinical interventions to (1) improve understanding of isolated elderly; and (2) identify potential strategies that would increase the quality of life of this vulnerable population.
Dr. Portacolone, a medical anthropologist, is interested in improving the health outcomes of older persons who live alone, with a particular emphasis on those with MCI or dementia. The Pepper Center supported her preliminary research to support a K23 application focused on the health outcomes of older persons living alone with dementia. Following the funding of her K23, the DMAC helped her with recruitment strategies, and we also advised on a successful application to the Alzheimer’s Association for additional funding. Dr. Portacolone was awarded a K01 from NIA entitled “Living Alone in Older Age with Cognitive Impairment.” In addition, she was awarded a New Investigator Award from the Alzheimer’s Association to better understand the experience of older adults from ethnic/racial minorities living alone with Alzheimer’s dementia and mild cognitive impairment. She was awarded a UCSF School of Nursing award along with an award from the UCSF Chancellor Fund.