Publications

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Nature methods

Sparse PCA corrects for cell type heterogeneity in epigenome-wide association studies.

2016

Authors: Rahmani E, Zaitlen N, Baran Y, Eng C, Hu D, Galanter J, Oh S, Burchard EG, Eskin E, Zou J, Halperin E

The Journal of allergy and clinical immunology

Assessing differences in inhaled corticosteroid response by self-reported race-ethnicity and genetic ancestry among asthmatic subjects.

2016

Authors: Wells KE, Cajigal S, Peterson EL, Ahmedani BK, Kumar R, Lanfear DE, Burchard EG, Williams LK

Psychological medicine

Somatic, positive and negative domains of the Center for Epidemiological Studies Depression (CES-D) scale: a meta-analysis of genome-wide association studies.

2016

Authors: Demirkan A, Lahti J, Direk N, Viktorin A, Lunetta KL, Terracciano A, Nalls MA, Tanaka T, Hek K, Fornage M, Wellmann J, Cornelis MC, Ollila HM, Yu L, Smith JA, Pilling LC, Isaacs A, Palotie A, Zhuang WV, Zonderman A, Faul JD, Sutin A, Meirelles O, Mulas A, Hofman A, Uitterlinden A, Rivadeneira F, Perola M, Zhao W, Salomaa V, Yaffe K, Luik AI, Liu Y, Ding J, Lichtenstein P, Landén M, Widen E, Weir DR, Llewellyn DJ, Murray A, Kardia SL, Eriksson JG, Koenen K, Magnusson PK, Ferrucci L, Mosley TH, Cucca F, Oostra BA, Bennett DA, Paunio T, Berger K, Harris TB, Pedersen NL, Murabito JM, Tiemeier H, van Duijn CM, Räikkönen K

PloS one

Racial Differences in Left Atrial Size: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

2016

Authors: Dewland TA, Bibbins-Domingo K, Lin F, Vittinghoff E, Foster E, Ogunyankin KO, Lima JA, Jacobs DR, Hu D, Burchard EG, Marcus GM

JAMA

Dextromethorphan-Quinidine for Agitation in Alzheimer Disease.

2016

Authors: Newman JC, Steinman MA

Journal of geriatric oncology

Novel physical activity interventions for older patients with prostate cancer on hormone therapy: A pilot randomized study.

2016

Authors: Sajid S, Dale W, Mustian K, Kotwal A, Heckler C, Porto M, Fung C, Mohile SG

American journal of respiratory and critical care medicine

Making Precision Medicine Socially Precise. Take a Deep Breath.

2016

Authors: Oh SS, White MJ, Gignoux CR, Burchard EG

Journal of the American Geriatrics Society | Volume 64 of Issue 2

Pattern of Emotional Benefits Induced by Regular Singing and Music Listening in Dementia.

2016

Authors: Särkämö T, Laitinen S, Numminen A, Kurki M, Johnson JK, Rantanen P

JAMA internal medicine

An Intervention to Reduce Use of Low-Value Imaging Tests.

2016

Authors: Covinsky KE, Redberg RF

The Laryngoscope | Volume 126 of Issue 9

Quality of life after intervention with a cochlear implant or hearing aid.

2016

Authors: Contrera KJ, Betz J, Li L, Blake CR, Sung YK, Choi JS, Lin FR

View Abstract

OBJECTIVES/HYPOTHESIS

To investigate the impact of hearing aid and cochlear implant use on quality of life in adults.

STUDY DESIGN

Prospective observational cohort study.

METHODS

One hundred thirteen adults aged ≥50 years with postlingual hearing loss receiving routine clinical care at a tertiary academic medical center were evaluated with the Medical Outcome Study Short Form-36 before and 6 and 12 months after intervention with hearing aids or cochlear implants. Change in score was assessed using linear mixed effect models adjusted for age, gender, education, and history of hypertension, diabetes, and smoking.

RESULTS

A significant increase in Mental Component Summary score was observed in both hearing aid and cochlear implant users from baseline to 12 months, with cochlear implant users increasing nearly twice that of hearing aid users (hearing aid: 2.49 [95% confidence interval: 0.11, 4.88], P = .041; cochlear implant: 4.20 [95% confidence interval: 1.85, 6.55], P < .001). The most substantial increases were observed in individuals with the lowest baseline scores. There was no significant difference in physical component summary score from baseline to 12 months.

CONCLUSIONS

Treatment of hearing loss with hearing aids and cochlear implants results in significant increases in mental health quality of life. The majority of the increase is observed by 6 months post-treatment, and we observed differential effects of treatment depending on the level of baseline quality of life score with the greatest gains observed in those with the lowest scores.

LEVEL OF EVIDENCE

2b. Laryngoscope, 126:2110-2115, 2016.

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