Drug and Alcohol Dependence
Authors: Marianna Wetherill, Casey Bakhsh, Lacey Caywood, Spencer Hall, Mary Williams, Micah Hartwell, Sheri Weiser
Drug and Alcohol Dependence
Authors: Lacey Caywood, Marianna Wetherill, Casey Bakhsh, Spencer Hall, Mary Williams, Micah Hartwell, Sheri Weiser
Journal of acquired immune deficiency syndromes (1999)
Authors: Maya S, Sheira LA, Frongillo EA, Pala AN, Kempf MC, Konkle-Parker D, Wilson TE, Tien PC, Wingood G, Topper EF, Neilands TB, Johnson MO, Logie CH, Weiser SD, Turan JM, Turan B
JAMA internal medicine | Volume 185 of Issue 2
Authors: Santoyo-Olsson J, Li L, Harrison KL
Human brain mapping
Authors: Wisch JK, Petersen K, Millar PR, Abdelmoity O, Babulal GM, Meeker KL, Braskie MN, Yaffe K, Toga AW, O'Bryant S, Ances BM, HABS-HD Study Team
Environmental health perspectives
Authors: Ndovu A, Chen C, Schwarz L, Lasky E, Weiser SD, Benmarhnia T
medRxiv : the preprint server for health sciences
Authors: Tanaka T, Rosano C, Huang X, Tian Q, Landman BA, Moore AZ, Miljkovic I, Perry A, Khan S, Kalhan R, Carr JJ, Terry JG, Yaffe K, Walker K, Candia J, Ferrucci L
Alzheimer's & dementia : the journal of the Alzheimer's Association
Authors: Jin J, Chen J, Cavaillès C, Yaffe K, Winer J, Stankeviciute L, Lucey BP, Zhou X, Gao S, Peng D, Leng Y
Circulation
Authors: Martin SS, Aday AW, Allen NB, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Bansal N, Beaton AZ, Commodore-Mensah Y, Currie ME, Elkind MSV, Fan W, Generoso G, Gibbs BB, Heard DG, Hiremath S, Johansen MC, Kazi DS, Ko D, Leppert MH, Magnani JW, Michos ED, Mussolino ME, Parikh NI, Perman SM, Rezk-Hanna M, Roth GA, Shah NS, Springer MV, St-Onge MP, Thacker EL, Urbut SM, Van Spall HGC, Voeks JH, Whelton SP, Wong ND, Wong SS, Yaffe K, Palaniappan LP, American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke St
Journal of the American Geriatrics Society | Volume 73 of Issue 5
Authors: Cohen I, Curiati PK, Morinaga CV, Han L, Gandhi T, Araujo K, Avelino-Silva TJ, Bianco LM, Brandt CA, Capelli S, Carpenter CR, Cruz DS, Dresden SM, Fishman IL, Gipson K, Gray E, Hastings SN, Hung WW, Kang R, Lockhart M, Meeker D, Ohuabunwa U, Ottilie-Kovelman S, Platts-Mills TF, Sandoval J, Sifnugel N, Taylor Z, Tomasino DF, Vaughan CP, Aliberti MJR, Hwang U
BACKGROUND
Existing risk scores assessing geriatric vulnerability in the emergency department (ED) have shown limited predictive power, especially in diverse populations. We investigated the relationship of a quick and easy-to-administer geriatric vulnerability scoring system with functional decline and mortality in older patients admitted to multiple hospitals through the ED in the United States (US) and Brazil (BR).
METHOD
Federated, international, multicenter observational study of hospitalized ED patients aged ≥ 65 from US and BR. The six criteria from the PRO-AGE score (Physical impairment, Recent hospitalization, Older age [≥ 90], Acute mental alteration, Getting thinner, and Exhaustion; 0-8; higher scores = greater vulnerability) were assessed on admission. We used proportional hazards models to investigate the relationships between PRO-AGE score groups and 90-day mortality and functional decline, defined as new dependence in activities of daily living (ADL) and instrumental ADL (IADL), after adjusting for age, sex, race and ethnicity, education, Charlson comorbidity score, and study site. Death was considered a competing event for the functional decline outcome.
RESULTS
A total of 1390 patients were included (US = 560; Brazil = 830). The 90-day risk of death was higher for the upper compared with the lower (reference) PRO-AGE group in both cohorts (US: HR = 11.76; 95% confidence interval [CI] = 2.56-54.04; BR: HR = 12.29; 95% CI = 3.54-42.59), whereas the risk of new 90-day ADL disability was higher for upper (HR = 2.08; 95% CI = 1.21-3.56) and middle groups (HR = 2.10; 95% CI = 1.35-3.27) in the US but only the upper group in BR (HR = 1.70; 95% CI = 1.02-2.85).
CONCLUSION
A higher PRO-AGE score was associated with mortality and functional decline in older ED patients admitted to hospitals in the US and BR, demonstrating its generalizability as a geriatric vulnerability risk score.
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