Journal of palliative medicine
Authors: Hunt LJ, Gan S, Smith AK, Aldridge MD, Boscardin WJ, Harrison KL, James JE, Lee AK, Yaffe K
Journal of the American Geriatrics Society
Authors: Kuang K, Huisingh-Scheetz M, Miller MJ, Waite L, Kotwal AA
Gynecologic oncology reports
Authors: Kay AH, Othieno A, Boscardin J, Chen LL, Alvarez EA, Swanson M, Ueda S, Chen LM, Chapman JS
Scientific Reports | Volume 13 of Issue 1
Authors: de Alencar JCG, Garcez FB, Pinto AAS, Silva LOJE, Soler LM, Fernandez SSM, Van Vaisberg V, Gomez Gomez LM, Ribeiro SML, Avelino-Silva TJ, Souza HP
Delirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood-brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between brain injury biomarkers on admission and delirium in acutely ill older patients. We performed a prospective cohort study which analyzed plasma S100B levels at admission in elderly patients. Our primary outcome was delirium diagnosis. Secondary outcomes were association between S100B, NSE and Tau protein and delirium diagnosis and patients' outcomes (admissions to intensive care, length of hospital stay, and in-hospital mortality). We analyzed 194 patients, and 46 (24%) developed delirium, 25 on admission and 21 during hospital stay. Median of S100B at admission in patients who developed delirium was 0.16 and median was 0.16 in patients who didn't develop delirium (p: 0.69). Levels S100B on admission did not predict delirium in acutely ill elderly patients.Trial registration: The study was approved by the local institutional review board (CAPPESq, no. 77169716.2.0000.0068, October 11, 2017) and registered in Brazilian Clinical Trials Registry (ReBEC, no. RBR-233bct).
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Basic & clinical pharmacology & toxicology
Authors: Reeve E, Thompson W, Boyd C, Lundby C, Steinman MA
medRxiv : the preprint server for health sciences
Authors: Shah SJ, van Walraven C, Jeon SY, Boscardin WJ, Hobbs FR, Connolly S, Ezekowitz M, Covinsky KE, Fang MC, Singer DE
Academic pediatrics
Authors: Congdon JL, Bardach NS, Franck LS, Brindis CD, John Boscardin W, Carrasco Z, Cabana MD, Dehlendorf C
BMC psychiatry
Authors: Zaman T, Bravata DM, Byers AL, Krebs EE, Leonard SJ, Sandbrink F, Barker W, Keyhani S
Neurology
Authors: Zhang Y, Liu X, Wiggins KL, Kurniansyah N, Guo X, Rodrigue AL, Zhao W, Yanek LR, Ratliff SM, Pitsillides A, Aguirre Pati?o JS, Sofer T, Arking DE, Austin TR, Beiser AS, Blangero J, Boerwinkle E, Bressler J, Curran JE, Hou L, Hughes TM, Kardia SL, Launer L, Levy D, Mosley TH, Nasrallah IM, Rich SS, Rotter JI, Seshadri S, Tarraf W, Gonz?lez KA, Ramachandran V, Yaffe K, Nyquist PA, Psaty BM, DeCarli CS, Smith JA, Glahn DC, Gonz?lez HM, Bis JC, Fornage M, Heckbert SR, Fitzpatrick AL, Liu C, Satizabal CL
PloS one
Authors: Chayama KL, Hufstedler EL, Whittle HJ, Nápoles TM, Seligman H, Madsen K, Frongillo EA, Weiser SD, Palar K
