Janice Schwartz, MD

Schwartz JB, Covinsky K. "Unjustified Partiality or Impartial Bias? Reckoning with Age and Disability Discrimination in Cancer Clinical Trials". 2024. PMID: 39676363

Tarn DM, Liu RY, Pun T, Schwartz JB. Navigating the Path to Inclusion: Understanding Barriers and Facilitators to Clinical Trial Participation Among Chinese Older Adults in the United States with Multimorbidity. 2024. PMID: 39495453

Gronich N, Saliba W, Schwartz JB. Prevalence and proportion by age and sex of chronic health conditions in a large healthcare system. 2024. PMID: 39325771

Schwartz JB. A paradigm shift in evaluation of new medications for older adults-A mandate has arrived! 2024. PMID: 38822639

Schwartz JB. Current status of inclusion of older groups in evaluations of new medications: Gaps and implementation needs to fill them. 2024. PMID: 38600697

Schwartz JB, Liu RY, Boscardin J, Liu Q, Lau SWJ, Khatri S, Tarn D. Attitudes on participation in clinical drug trials: A nationally representative survey of older adults with multimorbidity. 2024. PMID: 38485469

Schwartz JB. Representative enrolment of older adults in clinical trials: the time is now. 2023. PMID: 37263282

Tarn DM, Shih K, Tseng CH, Thomas A, Schwartz JB. Reasons for Nonadherence to the Direct Oral Anticoagulant Apixaban: A Cross-Sectional Survey of Atrial Fibrillation Patients. 2023. PMID: 38939023

Lau SWJ, Huang Y, Hsieh J, Wang S, Liu Q, Slattum PW, Schwartz JB, Huang SM, Temple R. Participation of Older Adults in Clinical Trials for New Drug Applications and Biologics License Applications From 2010 Through 2019. 2022. PMID: 36239939

Sukumar S, Orkaby AR, Schwartz JB, Marcum Z, Januzzi JL, Vaduganathan M, Warraich HJ. Polypharmacy in Older Heart Failure Patients: a Multidisciplinary Approach. 2022. PMID: 35723783

Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein, TE, Nutescu, EA, O’Brien, TJ, Tuck M, Perera M.A., Schwartz, JB. Apixaban Concentrations in Routine Clinical Care of Older Adults with Non-valvular Atrial Fibrillation 2022. PMID:

Thomas A, Fang MC, Kogan S, Hubbard CC, Friedman PN, Gong L, Klein TE, Nutescu EA, O'Brien TJ, Tuck M, Perera MA, Schwartz JB. Apixaban Concentrations in Routine Clinical Care of Older Adults With Nonvalvular Atrial Fibrillation. 2022. PMID: 37961076

Liu Q, Schwartz JB, Slattum PW, Lau SWJ, Guinn D, Madabushi R, Burckart G, Califf R, Cerreta F, Cho C, Cook J, Gamerman J, Goldsmith P, van der Graaf PH, Gurwitz JH, Haertter S, Hilmer S, Huang SM, Inouye SK, Kanapuru B, Pirmohamed M, Posner P, Radziszewska B, Talbot HK, Temple R. Roadmap To 2030 For Drug Evaluation In Older Adults. 2021. PMID: 34656074

Schwartz JB, Kogan SC, Fang MC. Preventing Bleeding With Direct-Acting Oral Anticoagulants. 2021. PMID: 34649705

Schwartz JB, Weintraub S. Treatment for Alzheimer Disease-Sex and Gender Effects Need to Be Explicitly Analyzed and Reported in Clinical Trials. 2021. PMID: 34515788

Tarn DM, Shih KJ, Schwartz JB. Reasons for nonadherence to the direct oral anticoagulant apixaban for atrial fibrillation. 2021. PMID: 34453325

Hilmer SN, Petrovic M, Le Couteur DG, Schwartz JB, Thuermann P. Development, evaluation and use of COVID-19 vaccines in older adults: Preliminary principles for the pandemic and beyond. 2021. PMID: 34342013

Slattum PW, Schwartz JB. A challenge: The American Geriatric Society needs to address the lack of inclusion of older adults in new drug evaluation. 2021. PMID: 34062612

Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB. Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study. 2021. PMID: 34013157

. Primary nonadherence to statin medications: Survey of patient perspectives. 2021. PMID: 33842201

Herr AE, Schwartz JB. Something Old and Something New: The Time Is Right for Geriatric Engineering Programs. 2021. PMID: 33421099

Tarn DM, Barrientos M, Pletcher MJ, Cox K, Turner J, Fernandez A, Schwartz JB. Perceptions of Patients with Primary Nonadherence to Statin Medications. 2021. PMID: 33452090

Tarn DM, Schwartz JB. Polypharmacy: A Five-Step Call to Action for Family Physicians. 2020. PMID: 33151528

Tarn DM, Barrientos M, Wang AY, Ramaprasad A, Fang MC, Schwartz JB. Prevalence and Knowledge of Potential Interactions Between Over-the-Counter Products and Apixaban. 2019. PMID: 31658372

Sukumar S, Gulilat M, Linton B, Gryn SE, Dresser GK, Alfonsi JE, Schwarz UI, Kim RB, Schwartz JB. Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation. 2019. PMID: 31112620

Zarowitz BJ, Nace DA, Brandt N, Schwartz JB. Pharmacotherapy Research Priorities in Older Adults With Cardiovascular Disease in Nursing Homes, Assisted Living, and Home Care: Report From a Satellite Symposium of the ACC, AGS, NIA Workshop. 2019. PMID: 30922866

Winston CN, Goetzl EJ, Schwartz JB, Elahi FM, Rissman RA. Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. 2019. PMID: 31032394

Schwartz JB, Schmader KE, Hanlon JT, Abernethy DR, Gray S, Dunbar-Jacob J, Holmes HM, Murray MD, Roberts R, Joyner M, Peterson J, Lindeman D, Tai-Seale M, Downey L, Rich MW. Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop. 2018. PMID: 30536694

Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. 2018. PMID: 29955795

Schwartz JB. Editorial Commentary: Blood pressure and cognition in the elderly. 2018. PMID: 30072095

Goetzl EJ, Nogueras-Ortiz C, Mustapic M, Mullins RJ, Abner EL, Schwartz JB, Kapogiannis D. Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease. 2018. PMID: 29924942

Moore KL, Patel K, Boscardin WJ, Steinman MA, Ritchie C, Schwartz JB. Medication burden attributable to chronic co-morbid conditions in the very old and vulnerable. 2018. PMID: 29684077

Goetzl EJ, Schwartz JB, Abner EL, Jicha GA, Kapogiannis D. High complement levels in astrocyte-derived exosomes of Alzheimer disease. 2018. PMID: 29406582

Schwartz JB, Woosley RL, Peck CC. Farewell to Our Good Friend, Outstanding Mentor, and Colleague Darrell R. Abernethy (1949-2017). 2018. PMID: 29435985

Goetzl EJ, Abner EL, Jicha GA, Kapogiannis D, Schwartz JB. Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease. 2018. PMID: 29025866

Schwartz JB. Authors Have Incorrectly Calculated Need for Renal Dose Adjustments for NOACs. 2017. PMID: 29169485

Schwartz J, Merrill S, de Leon N, Thompson A, Fang M. Dosing Accuracy of Direct Oral Anticoagulants in an Academic Medical Center. 2017. PMID: 28699943

Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. 2017. PMID: 28476896

Schwartz JB. Dabigatran Compared With Rivaroxaban vs Warfarin. 2017. PMID: 28460097

Schwartz JB, Rosano G, Channer KS. Letter to the Editor: "Effects of Testosterone Replacement on Electrocardiographic Parameters in Men: Findings From Two Randomized Trials". 2017. PMID: 28482077

Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK. Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients. 2017. PMID: 28070716

Schwartz, JB. Potential impact of substituting estimated Glomerular Filtration Rate for estimated Creatinine Clearance for dosing of Direct Oral Anticoagulants 2016. PMID:

Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL. Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease. 2016. PMID: 27601437

Schwartz JB. Potential Effect of Substituting Estimated Glomerular Filtration Rate for Estimated Creatinine Clearance for Dosing of Direct Oral Anticoagulants. 2016. PMID: 27549687

Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. 2016. PMID: 27511944

Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. 2016. PMID: 26782853

Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Kapogiannis D. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. 2015. PMID: 26062630

Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Carlson OD, Mustapic M, Kapogiannis D. Low neural exosomal levels of cellular survival factors in Alzheimer's disease. 2015. PMID: 26273689

Dai X, Hummel SL, Salazar JB, Taffet GE, Zieman S, Schwartz JB. Cardiovascular physiology in the older adults. 2015. PMID: 26089840

Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. 2015. PMID: 25757956

Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. 2014. PMID: 25342129

Schwartz JB. Primary prevention: do the very elderly require a different approach? 2014. PMID: 25560975

Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. 2014. PMID: 25130657

Steinman MA, Miao Y, Boscardin WJ, Komaiko KD, Schwartz JB. Prescribing quality in older veterans: a multifocal approach. 2014. PMID: 25002159

Moore KL, Boscardin WJ, Steinman MA, Schwartz JB. Patterns of chronic co-morbid medical conditions in older residents of U.S. nursing homes: differences between the sexes and across the agespan. 2014. PMID: 24676326

Schwartz JB, Moore KL, Yin M, Sharma A, Merenstein D, Islam T, Golub ET, Tien PC, Adeyemi OM. Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the Women's Interagency HIV Study of HIV-infected and uninfected women in the United States. 2014. PMID: 24668135

Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. 2013. PMID: 24240067

Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB. Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. 2013. PMID: 24030939

Mitsuhashi M, Taub DD, Kapogiannis D, Eitan E, Zukley L, Mattson MP, Ferrucci L, Schwartz JB, Goetzl EJ. Aging enhances release of exosomal cytokine mRNAs by Aß1-42-stimulated macrophages. 2013. PMID: 24014820

Steinman MA, Lee SJ, John Boscardin W, Miao Y, Fung KZ, Moore KL, Schwartz JB. Patterns of multimorbidity in elderly veterans. Volume 60 of Issue 10. 2012. PMID: 23035702

Taub DD, Hesdorffer CS, Ferrucci L, Madara K, Schwartz JB, Goetzl EJ. Distinct energy requirements for human memory CD4 T-cell homeostatic functions. 2012. PMID: 22972918

Moore KL, Boscardin WJ, Steinman MA, Schwartz JB. Age and sex variation in prevalence of chronic medical conditions in older residents of U.S. nursing homes. 2012. PMID: 22463062

Hesdorffer CS, Malchinkhuu E, Biragyn A, Mabrouk OS, Kennedy RT, Madara K, Taub DD, Longo DL, Schwartz JB, Ferrucci L, Goetzl EJ. Distinctive immunoregulatory effects of adenosine on T cells of older humans. 2011. PMID: 22121051

Goetzl EJ, Schwartz JB, Huang MC. Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia. 2011. PMID: 21671128

Schwartz JB, Volterrani M, Caminiti G, Marazzi G, Fini M, Rosano GM, Iellamo F. Effects of testosterone on the Q-T interval in older men and older women with chronic heart failure. 2011. PMID: 21615419

Schwartz JB, Kane L, Moore K, Wu AH. Failure of pharmacogenetic-based dosing algorithms to identify older patients requiring low daily doses of warfarin. 2011. PMID: 21450231

Huang MC, Greig NH, Luo W, Tweedie D, Schwartz JB, Longo DL, Ferrucci L, Ershler WB, Goetzl EJ. Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. 2010. PMID: 21130040

Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL. Gender specificity of altered human immune cytokine profiles in aging. 2010. PMID: 20453111

Schwartz JB, Verotta D. Population analyses of atorvastatin clearance in patients living in the community and in nursing homes. 2009. PMID: 19571802

Schwartz JB and Abernethy, DR. 2009; 85 (1): 3-10.. Clin Pharmacol Ther 2009. PMID:

Verotta D, Schwartz JB.. Clin Pharmacol Ther 2009. PMID:

Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: a new drug interaction with an unexpected consequence. 2008. PMID: 18754003

Schwartz JB. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. 2007. PMID: 17495875

Alexander KP, Chen AY, Newby LK, Schwartz JB, Redberg RF, Hochman JS, Roe MT, Gibler WB, Ohman EM, Peterson ED. Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. 2006. PMID: 16982940

Schwartz JB. Erythromycin breath test results in elderly, very elderly, and frail elderly persons. 2006. PMID: 16678546

Kang D, Verotta D, Schwartz JB. Population analyses of amlodipine in patients living in the community and patients living in nursing homes. 2006. PMID: 16413246

Kang D, Schwartz JB, Verotta D. Sample size computations for PK/PD population models. 2005. PMID: 16284914

Schwartz JB, Redberg RF. What does the Medicare prescription drug legislation mean for the American cardiologist? 2005. PMID: 16276130

Kadish AH, Greenland P, Limacher MC, Frishman WH, Daugherty SA, Schwartz JB. Estrogen and progestin use and the QT interval in postmenopausal women. 2004. PMID: 15485516

Kang D, Schwartz JB, Verotta D. A sample size computation method for non-linear mixed effects models with applications to pharmacokinetics models. 2004. PMID: 15287084

Schwartz JB. Sudden cardiac death among women in the United States. 2003. PMID: 14638535

Schwartz JB. Gender-specific implications for cardiovascular medication use in the elderly optimizing therapy for older women. 2003. PMID: 12943605

Kang D, Verotta D, Krecic-Shepard ME, Modi NB, Gupta SK, Schwartz JB. Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking. 2003. PMID: 12545141

Schwartz JB. The influence of sex on pharmacokinetics. 2003. PMID: 12537512

Haller C, Schwartz JB. Pharmacologic agents for weight reduction. 2002. PMID: 12380196

Schwartz JB. Peripheral arterial disease: drug therapy. 2002. PMID: 12192882

Schwartz JB. Pharmacogenetics: has it reached the clinic? 2002. PMID: 11974670

Schwartz JB. Anticoagulant and thrombolytic therapies in women. 2002. PMID: 11859682

Schwartz JB. Drug Interactions in the Elderly With Coronary Artery Disease - Do These Interfere With Effective Therapy? 1998. PMID: 11416440

Schwartz JB. Age-Related Pharmacodynamic Changes in the Elderly: Treatment Considerations in Heart Failure. 1996. PMID: 11416366