Janice Schwartz, MD

Professor of Medicine

I graduated from Tulane Medical School, am a board-certified internist and cardiologist with significant experience in clinical pharmacology and geriatric medicine. My research goal has been to elucidate age-related and sex-related differences in pharmacokinetics and pharmacodynamics in order to improve medication therapy for older adults. I have studied models of aging from in vitro models of cardiac changes with aging to physiologic and pharmacokinetic investigations of healthy humans to population studies of community dwelling elderly, and frail elderly adults.

My current work focuses on improving medication use in the very oldest people, in optimizing outcomes in older people receiving polypharmacy, and the translation and optimization of new therapeutic agents such as anticoagulants during clinical use to benefit the very oldest and frailest patients. I recently completed a ORISE visiting Professorship in the Office of Clinical Pharmacology at the FDA to stimulate initiatives to improve the drug evaluation and monitoring process for older adults and incorporate patient-centered outcomes into the drug evaluation process.
Education
1990 - Geriatrics, UCLA
1981 - Cardiology, Stanford University
1978 - Cardiology, Cedar Sinai Medical Center
1977 - Internal Medicine, Cedar-Sinai Medical Center
1975 - Internal Medicine, LACounty/USC
MD, 1974 - Medicine, Tulane University, School of Medicine
1970 - Biology, Newcomb College
Honors and Awards
  • Award of Excellence in Clinical Pharmacology, PhRMA, 2019
  • William Abrams Award in Geriatric Clinical Pharmacology, American Society of Clinical Pharmacology and Therapeutics, 2012
Websites
Publications
  1. Sukumar S, Orkaby AR, Schwartz JB, Marcum Z, Januzzi JL, Vaduganathan M, Warraich HJ. Polypharmacy in Older Heart Failure Patients: a Multidisciplinary Approach. 2022. PMID: 35723783


  2. Liu Q, Schwartz JB, Slattum PW, Lau SWJ, Guinn D, Madabushi R, Burckart G, Califf R, Cerreta F, Cho C, Cook J, Gamerman J, Goldsmith P, van der Graaf PH, Gurwitz JH, Haertter S, Hilmer S, Huang SM, Inouye SK, Kanapuru B, Pirmohamed M, Posner P, Radziszewska B, Talbot HK, Temple R. Roadmap To 2030 For Drug Evaluation In Older Adults. 2021. PMID: 34656074


  3. Schwartz JB, Kogan SC, Fang MC. Preventing Bleeding With Direct-Acting Oral Anticoagulants. 2021. PMID: 34649705


  4. Hilmer SN, Petrovic M, Le Couteur DG, Schwartz JB, Thuermann P. Development, evaluation and use of COVID-19 vaccines in older adults: Preliminary principles for the pandemic and beyond. 2021. PMID: 34342013


  5. Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB. Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study. 2021. PMID: 34013157


  6. Tarn DM, Barrientos M, Pletcher MJ, Cox K, Turner J, Fernandez A, Schwartz JB. Perceptions of Patients with Primary Nonadherence to Statin Medications. 2021. PMID: 33452090


  7. Tarn DM, Schwartz JB. Polypharmacy: A Five-Step Call to Action for Family Physicians. 2020. PMID: 33151528


  8. Tarn DM, Barrientos M, Wang AY, Ramaprasad A, Fang MC, Schwartz JB. Prevalence and Knowledge of Potential Interactions Between Over-the-Counter Products and Apixaban. 2019. PMID: 31658372


  9. Sukumar S, Gulilat M, Linton B, Gryn SE, Dresser GK, Alfonsi JE, Schwarz UI, Kim RB, Schwartz JB. Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation. 2019. PMID: 31112620


  10. Schwartz JB, Schmader KE, Hanlon JT, Abernethy DR, Gray S, Dunbar-Jacob J, Holmes HM, Murray MD, Roberts R, Joyner M, Peterson J, Lindeman D, Tai-Seale M, Downey L, Rich MW. Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop. 2018. PMID: 30536694


  11. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. 2018. PMID: 29955795


  12. Goetzl EJ, Nogueras-Ortiz C, Mustapic M, Mullins RJ, Abner EL, Schwartz JB, Kapogiannis D. Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease. 2018. PMID: 29924942


  13. Moore KL, Patel K, Boscardin WJ, Steinman MA, Ritchie C, Schwartz JB. Medication burden attributable to chronic co-morbid conditions in the very old and vulnerable. 2018. PMID: 29684077


  14. Goetzl EJ, Schwartz JB, Abner EL, Jicha GA, Kapogiannis D. High complement levels in astrocyte-derived exosomes of Alzheimer disease. 2018. PMID: 29406582


  15. Schwartz J, Merrill S, de Leon N, Thompson A, Fang M. Dosing Accuracy of Direct Oral Anticoagulants in an Academic Medical Center. 2017. PMID: 28699943


  16. Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. 2017. PMID: 28476896


  17. Schwartz JB. Dabigatran Compared With Rivaroxaban vs Warfarin. 2017. PMID: 28460097


  18. Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK. Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients. 2017. PMID: 28070716


  19. Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL. Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease. 2016. PMID: 27601437


  20. Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. 2016. PMID: 27511944


  21. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Kapogiannis D. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. 2015. PMID: 26062630


  22. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Carlson OD, Mustapic M, Kapogiannis D. Low neural exosomal levels of cellular survival factors in Alzheimer's disease. 2015. PMID: 26273689


  23. Dai X, Hummel SL, Salazar JB, Taffet GE, Zieman S, Schwartz JB. Cardiovascular physiology in the older adults. 2015. PMID: 26089840


  24. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. 2015. PMID: 25757956


  25. Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. 2014. PMID: 25342129


  26. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. 2014. PMID: 25130657


  27. Steinman MA, Miao Y, Boscardin WJ, Komaiko KD, Schwartz JB. Prescribing quality in older veterans: a multifocal approach. 2014. PMID: 25002159


  28. Schwartz JB, Moore KL, Yin M, Sharma A, Merenstein D, Islam T, Golub ET, Tien PC, Adeyemi OM. Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the Women's Interagency HIV Study of HIV-infected and uninfected women in the United States. 2014. PMID: 24668135


  29. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. 2013. PMID: 24240067


  30. Mitsuhashi M, Taub DD, Kapogiannis D, Eitan E, Zukley L, Mattson MP, Ferrucci L, Schwartz JB, Goetzl EJ. Aging enhances release of exosomal cytokine mRNAs by Aß1-42-stimulated macrophages. 2013. PMID: 24014820


  31. Steinman MA, Lee SJ, John Boscardin W, Miao Y, Fung KZ, Moore KL, Schwartz JB. Patterns of multimorbidity in elderly veterans. Volume 60 of Issue 10. 2012. PMID: 23035702


  32. Taub DD, Hesdorffer CS, Ferrucci L, Madara K, Schwartz JB, Goetzl EJ. Distinct energy requirements for human memory CD4 T-cell homeostatic functions. 2012. PMID: 22972918


  33. Moore KL, Boscardin WJ, Steinman MA, Schwartz JB. Age and sex variation in prevalence of chronic medical conditions in older residents of U.S. nursing homes. 2012. PMID: 22463062


  34. Hesdorffer CS, Malchinkhuu E, Biragyn A, Mabrouk OS, Kennedy RT, Madara K, Taub DD, Longo DL, Schwartz JB, Ferrucci L, Goetzl EJ. Distinctive immunoregulatory effects of adenosine on T cells of older humans. 2011. PMID: 22121051


  35. Schwartz JB, Volterrani M, Caminiti G, Marazzi G, Fini M, Rosano GM, Iellamo F. Effects of testosterone on the Q-T interval in older men and older women with chronic heart failure. 2011. PMID: 21615419


  36. Huang MC, Greig NH, Luo W, Tweedie D, Schwartz JB, Longo DL, Ferrucci L, Ershler WB, Goetzl EJ. Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. 2010. PMID: 21130040


  37. Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL. Gender specificity of altered human immune cytokine profiles in aging. 2010. PMID: 20453111


  38. Schwartz JB and Abernethy, DR. 2009; 85 (1): 3-10.. Clin Pharmacol Ther 2009. PMID:


  39. Verotta D, Schwartz JB.. Clin Pharmacol Ther 2009. PMID:


  40. Kang D, Schwartz JB, Verotta D. Sample size computations for PK/PD population models. 2005. PMID: 16284914


  41. Kadish AH, Greenland P, Limacher MC, Frishman WH, Daugherty SA, Schwartz JB. Estrogen and progestin use and the QT interval in postmenopausal women. 2004. PMID: 15485516


  42. Schwartz JB. Sudden cardiac death among women in the United States. 2003. PMID: 14638535


  43. Kang D, Verotta D, Krecic-Shepard ME, Modi NB, Gupta SK, Schwartz JB. Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking. 2003. PMID: 12545141


  44. Schwartz JB. The influence of sex on pharmacokinetics. 2003. PMID: 12537512


  45. Haller C, Schwartz JB. Pharmacologic agents for weight reduction. 2002. PMID: 12380196


  46. Schwartz JB. Peripheral arterial disease: drug therapy. 2002. PMID: 12192882


  47. Schwartz JB. Pharmacogenetics: has it reached the clinic? 2002. PMID: 11974670


  48. Schwartz JB. Anticoagulant and thrombolytic therapies in women. 2002. PMID: 11859682